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KMID : 0378019740170091264
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New Medical Journal
1974 Volume.17 No. 9 p.1264 ~ p.1269
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A Clinical Study of Tavegyl^(®) on the Allergic Diseases
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張東翊/Chang, Dong Ik
李相龍/康석營/鄭泰仁/Lee, Sang Yong/Kang, Suck Young/Chung, Tae In
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Abstract
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Tavegyl®(1-methyl-2-{2-(a-methyl-p-chlorodiphenyl methyloxy) ethyl} pyrrolidine) is a new drug known to have potent antihistaminic effect with minimal sedative side effect which was developed recently in England. According to the report of Roeman & Weidmann, it had more potent degree of antihistaminic effect than that of classic antihistamines such as Chlorpheniramine or Thenalidine, and Coller claimed that it had less side reactions such as sedation than these drugs.
The authors have carried out a clinical study on the effect of Tavegyl® on the 44 patient who had allergic diseases.
The results are summarized as follows:
1) Tavegyl® had effect on 35(79.5%)"out of 44 total cases, on 14 (70%) out of 20 Allergic rhinitis cases, on 14(100%) out of 14 Acute urticaria cases, on 3 (100%) out of 3 Hay fever. cases and 1 (50%) out of 2 Fixed drug eruption cases, and no effect on the Eczema 1 case & the Ca ttact dermatitis 1 case.
2) Tavegyl® had minimal side effects such as drowsiness, nausea, dizziness or malaise on only 5 (11.4%) out of 44 cases (sedation was 9.1%).
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KEYWORD
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